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A complex mechanistic lung model
Chumchal, Ondřej ; Mišík, Ondrej (referee) ; Jedelský, Jan (advisor)
This bachelor thesis looks at review of published airway models, with purpose of finding best avaliable solution for extension of current BUT model, reaching 7th generation of branching. The main purpose of the thesis is expanding model further into lower generations. Secondly, it deals with possibilities of getting more realistic results by coming with influence of temperature and humidity. Two main approaches were chosen, which shall be further more explored and adopted into use in BUT model, those are glass bead and rod model. In order to make model as realistic as possible, dimensionless characteristics such as Reynolds number and ratio of inner surface and volume of each generation were calculated to match those in real human lungs. The thesis concerns expansion down to 12th generation. Further calculation of deposition and flow parametres should be done, in order to verify mentioned approach.
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Use of fluorescent techniques in study of aerosol deposition
Lippay, Josef ; Jedelský, Jan (referee) ; Mravec, Filip (advisor)
Several experiments were designed for utilization of fluorescence spectroscopy as a method of aerosol particle detection in a model of lungs. One of the experiments was to arranged use luminescent properties of DEHS (bis(2-ethylhexyl)decandioate) for calculating aerosol deposition. The outcome of this experiment was confirmation of clusters existence, which causes luminescence of DEHS. But the luminescence is not enough dependent on concentration and as such is not suitable for calculation of aerosol deposition. As the next experiment DEHS-fluorescein particles were generated by condensation monodisperse aerosol generator (CMAG), where water was used instead of isopropyl alcohol as a solvent. By this alteration the negative influence of DEHS was eliminated, which caused results refinements of aerosol deposition. Generation of fluorescein sodium salt particles by small-scale powder disperser (SSPD) was designed as a last experiment. The lower deposition efficiency measured by this method was caused by particles polydispersion. Photo records were used for documentation of Hot-spots. Outcomes of this study are new knowledge of fluorescence spectroscopy utilization for study of aerosol deposition and possibilities of fluorescent aerosol particles generation. Acquired data can serve for knowledge extension of possible detection methods for aerosol particles in the model of lung and can serve for validation of numerical simulations.
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Experimental Research on Aerosol Transport and Deposition in a Human Respiratory Tract
Lízal, František ; Janotková, Eva (referee) ; Adamec, Vladimír (referee) ; Jícha, Miroslav (advisor)
Human health is significantly influenced by inhaled aerosols. Insight to the aerosol transport and deposition mechanisms is a prerequisite for both, toxicological protection against harmful particles and efficient application of inhaled therapeutic aerosols. The purpose of this doctoral thesis was to gain new knowledge of this topic on the basis of in vitro measurements. Phase-Doppler Anemometry was chosen for aerosol transport measurement, for it allows simultaneous measurement of particle size and velocity. Results were processed by means of statistical methods and frequency analysis. Deposition of spherical aerosol particles was measured by Positron Emission Tomography, while deposition of fibrous aerosol was measured by Phase-Contrast Microscopy combined with automated image analysis. All experiments were performed on physical models created on the basis of the real lung geometry. New knowledge of flow characteristics, transition from laminar to turbulent flow, effect of breathing pattern or particle size on aerosol transport and deposition in human lungs are outcomes of this work. Significant effect of the oral cavity was ascertained due to comparison of aerosol deposition in realistic and semi-realistic model with cylindrical smooth walls. Acquired data not merely extended our knowledge of aerosol behavior in lungs but it can also be used for validation of numerical simulations.
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A complex mechanistic lung model
Chumchal, Ondřej ; Mišík, Ondrej (referee) ; Jedelský, Jan (advisor)
This bachelor thesis looks at review of published airway models, with purpose of finding best avaliable solution for extension of current BUT model, reaching 7th generation of branching. The main purpose of the thesis is expanding model further into lower generations. Secondly, it deals with possibilities of getting more realistic results by coming with influence of temperature and humidity. Two main approaches were chosen, which shall be further more explored and adopted into use in BUT model, those are glass bead and rod model. In order to make model as realistic as possible, dimensionless characteristics such as Reynolds number and ratio of inner surface and volume of each generation were calculated to match those in real human lungs. The thesis concerns expansion down to 12th generation. Further calculation of deposition and flow parametres should be done, in order to verify mentioned approach.
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Experimental Research on Aerosol Transport and Deposition in a Human Respiratory Tract
Lízal, František ; Janotková, Eva (referee) ; Adamec, Vladimír (referee) ; Jícha, Miroslav (advisor)
Human health is significantly influenced by inhaled aerosols. Insight to the aerosol transport and deposition mechanisms is a prerequisite for both, toxicological protection against harmful particles and efficient application of inhaled therapeutic aerosols. The purpose of this doctoral thesis was to gain new knowledge of this topic on the basis of in vitro measurements. Phase-Doppler Anemometry was chosen for aerosol transport measurement, for it allows simultaneous measurement of particle size and velocity. Results were processed by means of statistical methods and frequency analysis. Deposition of spherical aerosol particles was measured by Positron Emission Tomography, while deposition of fibrous aerosol was measured by Phase-Contrast Microscopy combined with automated image analysis. All experiments were performed on physical models created on the basis of the real lung geometry. New knowledge of flow characteristics, transition from laminar to turbulent flow, effect of breathing pattern or particle size on aerosol transport and deposition in human lungs are outcomes of this work. Significant effect of the oral cavity was ascertained due to comparison of aerosol deposition in realistic and semi-realistic model with cylindrical smooth walls. Acquired data not merely extended our knowledge of aerosol behavior in lungs but it can also be used for validation of numerical simulations.
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|
|
Experimental research on aerosol transport and deposition in human respiratory tract
Lízal, František ; Jícha, Miroslav (advisor)
Human health is significantly influenced by inhaled aerosols. Insight to the aerosol transport and deposition mechanisms is a prerequisite for both, toxicological protection against harmful particles and efficient application of inhaled therapeutic aerosols. The purpose of this doctoral thesis was to gain new knowledge of this topic on the basis of in vitro measurements. Phase-Doppler Anemometry was chosen for aerosol transport measurement, for it allows simultaneous measurement of particle size and velocity. Results were processed by means of statistical methods and frequency analysis. Deposition of spherical aerosol particles was measured by Positron Emission Tomography, while deposition of fibrous aerosol was measured by Phase-Contrast Microscopy combined with automated image analysis. All experiments were performed on physical models created on the basis of the real lung geometry. New knowledge of flow characteristics, transition from laminar to turbulent flow, effect of breathing pattern or particle size on aerosol transport and deposition in human lungs are outcomes of this work. Significant effect of the oral cavity was ascertained due to comparison of aerosol deposition in realistic and semi-realistic model with cylindrical smooth walls. Acquired data not merely extended our knowledge of aerosol behavior in lungs but it can also be used for validation of numerical simulations.
|
|
|
Use of fluorescent techniques in study of aerosol deposition
Lippay, Josef ; Jedelský, Jan (referee) ; Mravec, Filip (advisor)
Several experiments were designed for utilization of fluorescence spectroscopy as a method of aerosol particle detection in a model of lungs. One of the experiments was to arranged use luminescent properties of DEHS (bis(2-ethylhexyl)decandioate) for calculating aerosol deposition. The outcome of this experiment was confirmation of clusters existence, which causes luminescence of DEHS. But the luminescence is not enough dependent on concentration and as such is not suitable for calculation of aerosol deposition. As the next experiment DEHS-fluorescein particles were generated by condensation monodisperse aerosol generator (CMAG), where water was used instead of isopropyl alcohol as a solvent. By this alteration the negative influence of DEHS was eliminated, which caused results refinements of aerosol deposition. Generation of fluorescein sodium salt particles by small-scale powder disperser (SSPD) was designed as a last experiment. The lower deposition efficiency measured by this method was caused by particles polydispersion. Photo records were used for documentation of Hot-spots. Outcomes of this study are new knowledge of fluorescence spectroscopy utilization for study of aerosol deposition and possibilities of fluorescent aerosol particles generation. Acquired data can serve for knowledge extension of possible detection methods for aerosol particles in the model of lung and can serve for validation of numerical simulations.
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